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Dennis van der Meijden isn’t intending to see the face of God, feel one with the cosmos, grasp the hidden reality of time and space, or start a sacred journey. What the Dutch graphic designer, manufacturer, and rap artist (under the professional name Terilekst) wants and gets from his twice-weekly „microdoses” of psilocybin is more modest.

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It makes him energetic enough to avoid coffee, „as if I’m begun some sort of orbit for that day.” If he becomes distracted, „I’m quite knowledgeable about that, as if seeing myself from a bird’s eye view, so I can fix myself extremely quick.” However van der Meijden says he takes care not to surpass about 0.

5 made him „a bit too cheerful and a bit too philosophical,” which wasn’t always suitable. Microdosing involves taking approximately one-tenth the „trip” dose of a psychedelic drug, a quantity insufficient to trigger hallucinations however enough, its advocates say, to sharpen the mind. Psilocybin microdosers (consisting of hundreds on Reddit) report that the mushrooms can increase imagination, calm stress and anxiety, decrease the need for caffeine, and reduce anxiety.

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But research study into microdosing is very little. In the almost 10 years since psychologist and psychedelics researcher James Fadiman presented the concept of microdosing and devised a commonly followed procedure for it, and three years after microdosing psychedelics became the most recent Silicon Valley „performance hack,” all the evidence about its effects has actually been anecdotal.

That is changing, nevertheless, as the Netherlands and other countries efficiently legalize it and scientists in locations where it remains prohibited acquire government approval to study it. The scientific interest is driven, in part, by many reports for many years that psilocybin might have antidepressant or anti-anxiety impacts that may assist the advancement of much better psychiatric drugs.

Now, in the very first study of its kind, scientists in the Netherlands discovered that psilocybin microdoses have no noticeable result on the problem-solving, rational-thinking, and abstract-reasoning ability called fluid intelligence. But they do appear to enhance 2 types of thinking that underlie imagination. „Performance was considerably greater” on tests of convergent and divergent thinking, said psychologist Bernhard Hommel of Leiden University in the Netherlands, who led the research study.

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Divergent thinking needs meandering psychological ventures and mental versatility. Psychologists consider both to be active ingredients of imagination. Whatever the dosage, psilocybin (O-phosphoryl-4-hydroxy-N, N-dimethyltryptamine) binds to receptors for the neurotransmitter serotonin. The cortex is loaded with these 5-HT2A receptors, especially in locations that manage reflection, creativity, and introspection, but „whether there is a minimum dose [of psilocybin that’s needed to activate them] is an empirical question that we attempt to deal with,” Hommel stated.

Leiden’s Luisa Prochazkova took the lead in welcoming members of the Psychedelic Society of the Netherlands to take part in the study; she got 38 takers. Before their microdose, the volunteers took three standard psychological tests, two related to imaginative problem-solving and one an assessment of fluid intelligence. The researchers ran chemical analyses of the mushroom samples to determine how much psilocybin they included.

33 grams. Participants averaged 0. 37 grams of the dried preparation, which can be taken with food or loaded into gelcaps for easy swallowing. About 90 minutes after the microdose, the individuals took the 3 tests again. In the Image Principle Job, they saw three rows of three pictures, and had to select three one from each row that belonged.